siRNA Delivery by Stimuli-Sensitive Nanocarriers
نویسندگان
چکیده
منابع مشابه
Stimuli-responsive hybrid nanocarriers developed by controllable integration of hyperbranched PEI with mesoporous silica nanoparticles for sustained intracellular siRNA delivery
Small interfering RNA (siRNA) is a highly potent drug in gene-based therapy with the challenge being to deliver it in a sustained manner. The combination of mesoporous silica nanoparticles (MSNs) and polycations in the confined pore space allows for incorporation and controlled release of therapeutic siRNA payloads. We hereby constructed MSNs with expanded mesopores and pore-surface-hyperbranch...
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ژورنال
عنوان ژورنال: Current Pharmaceutical Design
سال: 2015
ISSN: 1381-6128
DOI: 10.2174/138161282131151013190410